Microsoft has released the beta of BizTalk Server 2013. This means that the initial name BizTalk 2010 R2 has been changed. You can download the beta here:

http://www.microsoft.com/en-us/download/details.aspx?id=35553

This new release contains some new features:

Yesterday Microsoft released the cumulative update package 4 for BizTalk Server 2010. For more info please check the Microsoft support page:

http://support.microsoft.com/kb/2667310

The cumulative update package contains al previously released hotfixes. Before installing please read the following warning from Microsoft: