I recently published an article on TechNet Wiki explaining how to install Microsoft BizTalk Server 2010 on a basic multi-server. However, when I was analyzing my BizTalk environment with BizTalk Server Best Practice Analyser tool, has appeared a warning that caught my attention:
Privilege Attribute Certificate (PAC) Signature Validation is Enabled on Server BTS2010LAB01.
On server BTS2010LAB01, Privilege Attribute Certificate (PAC) signature is enabled, which may cause some user-authentication delay
And led me to go deeper in trying to see what was causing this strange issue and I found a number of TCP settings that needs to be done (or is recommended) which can also prevent from occurring general network errors on BizTalk Server Environments.